| Gene Information | |
|---|---|
| Gene Name | LPAR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) |
| Target Name | lysophosphatidic acid receptor 1 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000198121 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q92633 |
| Gene Card | LPAR1 |
| Uniprot ID | Q92633 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.023185345) |
| Ortholog in Animals | Alpaca_ LPAR1 ( ortholog_one2one ) Dog_ LPAR1 ( ortholog_one2one ) GuineaPig_ LPAR1 ( ortholog_one2one ) Mouse_ Lpar1 ( ortholog_one2one ) Rat_ Lpar1 ( ortholog_one2one ) Rabbit_ LPAR1 ( ortholog_one2one ) |
| Ohnologs | LPAR2, S1PR4, S1PR5, S1PR3, S1PR1, LPAR3 |
| Paralogs | GPR3, GPR119, GPR6, GPR12, CNR1, CNR2, MC5R, MC1R, MC2R, MC3R, MC4R, S1PR1, S1PR5, S1PR2, S1PR3, S1PR4, LPAR2, LPAR3 |
| Tissue | NA |
| Tissue Specificity | Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858). Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075). Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258). {ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:9070858}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4Z34 (X-ray 3.00A ) 4Z35 (X-ray 2.90A ) 4Z36 (X-ray 2.90A ) 7TD0 (EM 2.83A ) 7TD1 (EM 3.08A ) 7TD2 (EM 3.11A ) |
| DBSNP | rs11542862 |
| Subcellular location [CC] | Cell surface {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:25025571}. Cell membrane {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:26091040}. Endosome {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment. {ECO:0000269|PubMed:19306925}. |
| Mouse PG classification | NA |
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