| Gene Information | |
|---|---|
| Gene Name | CLIP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1438 |
| Protein Names | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000130779 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P30622 |
| Gene Card | CLIP1 |
| Uniprot ID | P30622 |
| Pfam | PF01302; PF16641 |
| In ASD | no |
| Allosteric Prediction | yes (0.270143484) |
| Ortholog in Animals | Alpaca_ CLIP1 ( ortholog_one2one ) Dog_ CLIP1 ( ortholog_one2one ) GuineaPig_ CLIP1 ( ortholog_one2one ) Macaque_ CLIP1 ( ortholog_one2one ) Mouse_ Clip1 ( ortholog_one2one ) Pig_ CLIP1 ( ortholog_one2one ) Rat_ Clip1 ( ortholog_one2one ) Rabbit_ CLIP1 ( ortholog_one2one ) |
| Ohnologs | CLIP2 |
| Paralogs | CLIP4, CLIP3, CLIP2, DCTN1 |
| Tissue | NA |
| Tissue Specificity | Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:1600942}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CP5 (NMR - ) 2CP6 (NMR - ) 2E3H (X-ray 1.45A ) 2E3I (X-ray 2.00A ) 2E4H (NMR - ) 2HQH (X-ray 1.80A ) 2QK0 (X-ray 2.00A ) 3E2U (X-ray 2.60A ) 3RDV (X-ray 1.75A ) |
| DBSNP | rs7963597 rs3741447 rs17883517 rs1129167 rs1183319975 rs17881033 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12433698}; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle {ECO:0000269|PubMed:12433698}. Note=Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). {ECO:0000250|UniProtKB:Q922J3, ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17889670, ECO:0000269|PubMed:21646404}. |
| Mouse PG classification | NA |
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