Gene Information
Gene NamePLCE1
OrganismHomo sapiens (Human)
Gene Length2302
Protein Names1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)
Target NameNA
Target TypeNA
Gene Age810 ( ENSG00000138193 )
Evolutionary StageEukaryota
AlphaFoldDBQ9P212
Gene CardPLCE1
Uniprot IDQ9P212
PfamPF00168; PF09279; PF00388; PF00387; PF00788; PF00617
In ASDno
Allosteric Predictionyes (0.295714564)
Ortholog in AnimalsAlpaca_ PLCE1 ( ortholog_one2one )
Dog_ PLCE1 ( ortholog_one2one )
GuineaPig_ PLCE1 ( ortholog_one2one )
Macaque_ PLCE1 ( ortholog_one2one )
Mouse_ Plce1 ( ortholog_one2one )
Pig_ PLCE1 ( ortholog_one2one )
Rat_ Plce1 ( ortholog_one2one )
Rabbit_ PLCE1 ( ortholog_one2one )
OhnologsNA
ParalogsPLCG2, PLCD3, PLCB3, PLCG1, PLCB1, PLCD4, PLCD1, PLCB2, PLCB4, PLCL2, PLCH1, PLCL1, PLCZ1, PLCH2
TissueNA
Tissue SpecificityWidely expressed. Expressed in podocytes (PubMed:29058690). {ECO:0000269|PubMed:15558028, ECO:0000269|PubMed:29058690}.;
[Isoform 1]: Broadly expressed and only absent in peripheral blood leukocytes. {ECO:0000269|PubMed:11022048, ECO:0000269|PubMed:15558028}.;
[Isoform 2]: Specifically expressed in placenta, lung and spleen. {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:15558028}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2BYE  (NMR  -  )  2BYF  (NMR  -  )  2C5L  (X-ray  1.90A  ) 
DBSNP rs17508082  rs17417407  rs121912605  rs2274224  rs3765524  rs2274223 
Subcellular location [CC]Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium {ECO:0000269|PubMed:29058690}. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes.
Mouse PG classificationLPG
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