| Gene Information | |
|---|---|
| Gene Name | PLCD4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 762 |
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000115556 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BRC7 |
| Gene Card | PLCD4 |
| Uniprot ID | Q9BRC7 |
| Pfam | PF00168; PF13202; PF09279; PF00169; PF00388; PF00387 |
| In ASD | no |
| Allosteric Prediction | no (-0.520408394) |
| Ortholog in Animals | Alpaca_ PLCD4 ( ortholog_one2one ) Dog_ PLCD4 ( ortholog_one2one ) GuineaPig_ PLCD4 ( ortholog_one2one ) Macaque_ PLCD4 ( ortholog_one2one ) Mouse_ Plcd4 ( ortholog_one2one ) Pig_ PLCD4 ( ortholog_one2one ) Rat_ Plcd4 ( ortholog_one2one ) Rabbit_ PLCD4 ( ortholog_one2one ) |
| Ohnologs | PLCD3, PLCD1 |
| Paralogs | PLCG2, PLCD3, PLCB3, PLCE1, PLCG1, PLCB1, PLCD1, PLCB2, PLCB4, PLCL2, PLCH1, PLCL1, PLCZ1, PLCH2 |
| Tissue | skeletal.muscle, sigmoid.colon |
| Tissue Specificity | Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. {ECO:0000269|PubMed:15140260, ECO:0000269|PubMed:15505048}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15140260}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum. |
| Mouse PG classification | NA |
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