| Gene Information | |
|---|---|
| Gene Name | FIR |
| Organism | Homo sapiens (Human) |
| Gene Length | 559 |
| Protein Names | Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UHX1 |
| Gene Card | PUF60 |
| Uniprot ID | Q9UHX1 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed in colonic epithelium and colorectal epithelium cancer (at protein level). Isoform 6 is expressed in colorectal epithelial cancer but below detection level in colonic epithelium. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:10668799, ECO:0000269|PubMed:16452196}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2DNY (NMR - ) 2KXF (NMR - ) 2KXH (NMR - ) 2QFJ (X-ray 2.10A ) 3DXB (X-ray 2.20A ) 3UE2 (X-ray 1.23A ) 3US5 (X-ray 1.38A ) 3UWT (X-ray 2.50A ) 5KVY (X-ray 1.95A ) 5KW1 (X-ray 2.10A ) 5KW6 (X-ray 1.91A ) 5KWQ (X-ray 2.80A ) 6LUR (X-ray 2.00A ) 6SLO (X-ray 1.94A ) |
| DBSNP | rs398123001 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10606266, ECO:0000269|PubMed:10668799, ECO:0000269|PubMed:17579712}. Note=Colocalizes partially with RO60. {ECO:0000269|PubMed:10668799}. |
| Mouse PG classification | NA |
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