| Gene Information | |
|---|---|
| Gene Name | PLCB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1185 |
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-2) (Phospholipase C-beta-2) (PLC-beta-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000137841 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q00722 |
| Gene Card | PLCB2 |
| Uniprot ID | Q00722 |
| Pfam | PF00168; PF09279; PF17787; PF00388; PF00387; PF08703 |
| In ASD | no |
| Allosteric Prediction | yes (1.130788501) |
| Ortholog in Animals | Alpaca_ PLCB2 ( ortholog_one2one ) Dog_ PLCB2 ( ortholog_one2one ) GuineaPig_ PLCB2 ( ortholog_one2one ) Macaque_ PLCB2 ( ortholog_one2one ) Mouse_ Plcb2 ( ortholog_one2one ) Pig_ PLCB2 ( ortholog_one2one ) Rat_ Plcb2 ( ortholog_one2one ) Rabbit_ PLCB2 ( ortholog_one2one ) |
| Ohnologs | PLCB4, PLCB1, PLCB3 |
| Paralogs | PLCG2, PLCD3, PLCB3, PLCE1, PLCG1, PLCB1, PLCD4, PLCD1, PLCB4, PLCL2, PLCH1, PLCL1, PLCZ1, PLCH2 |
| Tissue | adipose.tissue, spleen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2FJU (X-ray 2.20A ) 2ZKM (X-ray 1.62A ) |
| DBSNP | rs45628633 rs8025153 rs9972332 rs28395835 rs936212 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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