Gene Information
Gene NamePLAUR
OrganismHomo sapiens (Human)
Gene Length335
Protein NamesUrokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)
Target Nameurokinase plasminogen activator surface receptor
Target TypeNA
Gene Age382 ( ENSG00000011422 )
Evolutionary StageMammalia
AlphaFoldDBQ03405
Gene CardPLAUR
Uniprot IDQ03405
PfamPF00021
In ASDyes
Allosteric Predictionyes (0.99991129)
Ortholog in AnimalsAlpaca_ PLAUR ( ortholog_one2one )
GuineaPig_ PLAUR ( ortholog_one2one )
Macaque_ PLAUR ( ortholog_one2one )
Mouse_ Plaur ( ortholog_one2one )
Pig_ PLAUR ( ortholog_one2one )
Rat_ Plaur ( ortholog_one2one )
Rabbit_ PLAUR ( ortholog_one2one )
OhnologsNA
ParalogsLYPD5, LYPD3
Tissuelung
Tissue SpecificityExpressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1YWH  (X-ray  2.70A  )  2FD6  (X-ray  1.90A  )  2I9B  (X-ray  2.80A  )  3BT1  (X-ray  2.80A  )  3BT2  (X-ray  2.50A  )  3U73  (X-ray  3.19A  )  3U74  (X-ray  2.39A  )  4K24  (X-ray  4.50A  )  4QTI  (X-ray  3.00A  )  7E17  (X-ray  2.96A  )  7V63  (X-ray  2.91A  ) 
DBSNP rs4251813  rs399145  rs4251878  rs2302524  rs4251921  rs16976608  rs4760 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12376466}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269|PubMed:12376466}.;
[Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:P49616};
Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P49616}.;
[Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}.
Mouse PG classificationNA
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