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Gene Information
Gene Name
PLAU
Organism
Homo sapiens (Human)
Gene Length
431
Protein Names
Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
Target Name
urokinase-type plasminogen activator
Target Type
NA
Gene Age
680 ( ENSG00000122861 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P00749
Gene Card
PLAU
Uniprot ID
P00749
Pfam
PF00051; PF00089
In ASD
no
Allosteric Prediction
yes (1.305921213)
Ortholog in Animals
Alpaca_ PLAU ( ortholog_one2one )
Dog_ PLAU ( ortholog_one2one )
GuineaPig_ PLAU ( ortholog_one2one )
Macaque_ PLAU ( ortholog_one2one )
Mouse_ Plau ( ortholog_one2one )
Pig_ PLAU ( ortholog_one2one )
Rat_ Plau ( ortholog_one2one )
Rabbit_ PLAU ( ortholog_one2one )
Ohnologs
HABP2, PLAT, HGFAC, F12
Paralogs
PRSS1, PRSS3, PRSS2
Tissue
NA
Tissue Specificity
Expressed in the prostate gland and prostate cancers. {ECO:0000269|PubMed:15988036}.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.057143(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1C5W
(X-ray
1.94A
)
1C5X
(X-ray
1.75A
)
1C5Y
(X-ray
1.65A
)
1C5Z
(X-ray
1.85A
)
1EJN
(X-ray
1.80A
)
1F5K
(X-ray
1.80A
)
1F5L
(X-ray
2.10A
)
1F92
(X-ray
2.60A
)
1FV9
(X-ray
3.00A
)
1GI7
(X-ray
1.79A
)
1GI8
(X-ray
1.75A
)
1GI9
(X-ray
1.80A
)
1GJ7
(X-ray
1.50A
)
1GJ8
(X-ray
1.64A
)
1GJ9
(X-ray
1.80A
)
1GJA
(X-ray
1.56A
)
1GJB
(X-ray
1.90A
)
1GJC
(X-ray
1.73A
)
1GJD
(X-ray
1.75A
)
1KDU
(NMR
-
)
1LMW
(X-ray
2.50A
)
1O3P
(X-ray
1.81A
)
1O5A
(X-ray
1.68A
)
1O5B
(X-ray
1.85A
)
1O5C
(X-ray
1.63A
)
1OWD
(X-ray
2.32A
)
1OWE
(X-ray
1.60A
)
1OWH
(X-ray
1.61A
)
1OWI
(X-ray
2.93A
)
1OWJ
(X-ray
3.10A
)
1OWK
(X-ray
2.80A
)
1SC8
(X-ray
2.40A
)
1SQA
(X-ray
2.00A
)
1SQO
(X-ray
1.84A
)
1SQT
(X-ray
1.90A
)
1U6Q
(X-ray
2.02A
)
1URK
(NMR
-
)
1VJ9
(X-ray
2.40A
)
1VJA
(X-ray
2.00A
)
1W0Z
(X-ray
1.90A
)
1W10
(X-ray
2.00A
)
1W11
(X-ray
2.00A
)
1W12
(X-ray
2.40A
)
1W13
(X-ray
2.00A
)
1W14
(X-ray
2.20A
)
2FD6
(X-ray
1.90A
)
2I9A
(X-ray
1.90A
)
2I9B
(X-ray
2.80A
)
2NWN
(X-ray
2.15A
)
2O8T
(X-ray
1.45A
)
2O8U
(X-ray
1.70A
)
2O8W
(X-ray
1.86A
)
2R2W
(X-ray
2.01A
)
2VIN
(X-ray
1.90A
)
2VIO
(X-ray
1.80A
)
2VIP
(X-ray
1.72A
)
2VIQ
(X-ray
2.00A
)
2VIV
(X-ray
1.72A
)
2VIW
(X-ray
2.05A
)
2VNT
(X-ray
2.20A
)
3BT1
(X-ray
2.80A
)
3BT2
(X-ray
2.50A
)
3IG6
(X-ray
1.83A
)
3KGP
(X-ray
2.35A
)
3KHV
(X-ray
2.35A
)
3KID
(X-ray
2.71A
)
3M61
(X-ray
1.68A
)
3MHW
(X-ray
1.45A
)
3MWI
(X-ray
2.03A
)
3OX7
(X-ray
1.58A
)
3OY5
(X-ray
2.31A
)
3OY6
(X-ray
2.31A
)
3PB1
(X-ray
2.30A
)
3QN7
(X-ray
1.90A
)
3U73
(X-ray
3.19A
)
4DVA
(X-ray
1.94A
)
4DW2
(X-ray
2.97A
)
4FU7
(X-ray
2.00A
)
4FU8
(X-ray
2.20A
)
4FU9
(X-ray
1.60A
)
4FUB
(X-ray
1.90A
)
4FUC
(X-ray
1.72A
)
4FUD
(X-ray
2.00A
)
4FUE
(X-ray
2.00A
)
4FUF
(X-ray
2.00A
)
4FUG
(X-ray
1.80A
)
4FUH
(X-ray
1.60A
)
4FUI
(X-ray
2.00A
)
4FUJ
(X-ray
2.05A
)
4GLY
(X-ray
1.52A
)
4H42
(X-ray
2.01A
)
4JK5
(X-ray
1.55A
)
4JK6
(X-ray
2.20A
)
4K24
(X-ray
4.50A
)
4MNV
(X-ray
1.80A
)
4MNW
(X-ray
1.49A
)
4MNX
(X-ray
1.85A
)
4MNY
(X-ray
1.70A
)
4OS1
(X-ray
2.20A
)
4OS2
(X-ray
1.79A
)
4OS4
(X-ray
2.00A
)
4OS5
(X-ray
2.26A
)
4OS6
(X-ray
1.75A
)
4OS7
(X-ray
2.00A
)
4X0W
(X-ray
2.10A
)
4X1N
(X-ray
1.80A
)
4X1P
(X-ray
1.60A
)
4X1Q
(X-ray
2.28A
)
4X1R
(X-ray
2.10A
)
4X1S
(X-ray
1.90A
)
4XSK
(X-ray
1.50A
)
4ZHL
(X-ray
2.06A
)
4ZHM
(X-ray
1.90A
)
4ZKN
(X-ray
1.36A
)
4ZKO
(X-ray
1.29A
)
4ZKR
(X-ray
1.36A
)
4ZKS
(X-ray
1.85A
)
5HGG
(X-ray
1.97A
)
5WXF
(X-ray
1.46A
)
5WXO
(X-ray
1.64A
)
5WXP
(X-ray
1.75A
)
5WXQ
(X-ray
1.79A
)
5WXR
(X-ray
1.75A
)
5WXS
(X-ray
2.30A
)
5WXT
(X-ray
2.10A
)
5XG4
(X-ray
3.00A
)
5YC6
(X-ray
1.18A
)
5YC7
(X-ray
2.00A
)
5Z1C
(X-ray
1.45A
)
5ZA7
(X-ray
1.70A
)
5ZA8
(X-ray
1.90A
)
5ZA9
(X-ray
1.62A
)
5ZAE
(X-ray
1.73A
)
5ZAF
(X-ray
1.65A
)
5ZAG
(X-ray
1.95A
)
5ZAH
(X-ray
2.98A
)
5ZAJ
(X-ray
1.65A
)
5ZC5
(X-ray
1.90A
)
6AG2
(X-ray
1.77A
)
6AG3
(X-ray
2.48A
)
6AG7
(X-ray
1.90A
)
6AG9
(X-ray
1.63A
)
6JYP
(X-ray
2.25A
)
6JYQ
(X-ray
1.75A
)
6L04
(X-ray
2.21A
)
6L05
(X-ray
2.49A
)
6NMB
(X-ray
2.30A
)
6XVD
(X-ray
1.40A
)
7DZD
(X-ray
2.00A
)
DBSNP
rs2227580
rs2227564
rs1050120
rs2227567
Subcellular location [CC]
Secreted {ECO:0000269|PubMed:24434139}.
Mouse PG classification
LPG
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