Home
Genetic Feature
Search By Gene Name
Search By Disease Name
Evolutionary Feature
Search By Gene Name
Search By Ohnolog
Search By Ortholog
Allosteric Protein
Drug
Browse
Browse By Gene Name
Browse By Drug Name
Browse By Disease Name
Browse By Evolutionary Stage
Help
Download
Gene Information
Gene Name
PLAU
Organism
Homo sapiens (Human)
Gene Length
431
Protein Names
Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
Target Name
urokinase-type plasminogen activator
Target Type
Successful target
Gene Age
680 ( ENSG00000122861 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P00749
Gene Card
PLAU
Uniprot ID
P00749
Pfam
PF00051; PF00089
In ASD
no
Allosteric Prediction
yes (1.305921213)
Ortholog in Animals
Alpaca_ PLAU ( ortholog_one2one )
Dog_ PLAU ( ortholog_one2one )
GuineaPig_ PLAU ( ortholog_one2one )
Macaque_ PLAU ( ortholog_one2one )
Mouse_ Plau ( ortholog_one2one )
Pig_ PLAU ( ortholog_one2one )
Rat_ Plau ( ortholog_one2one )
Rabbit_ PLAU ( ortholog_one2one )
Ohnologs
HABP2, PLAT, HGFAC, F12
Paralogs
PRSS1, PRSS3, PRSS2
Tissue
NA
Tissue Specificity
Expressed in the prostate gland and prostate cancers. {ECO:0000269|PubMed:15988036}.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.057143(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1C5W
(X-ray
1.94A
)
1C5X
(X-ray
1.75A
)
1C5Y
(X-ray
1.65A
)
1C5Z
(X-ray
1.85A
)
1EJN
(X-ray
1.80A
)
1F5K
(X-ray
1.80A
)
1F5L
(X-ray
2.10A
)
1F92
(X-ray
2.60A
)
1FV9
(X-ray
3.00A
)
1GI7
(X-ray
1.79A
)
1GI8
(X-ray
1.75A
)
1GI9
(X-ray
1.80A
)
1GJ7
(X-ray
1.50A
)
1GJ8
(X-ray
1.64A
)
1GJ9
(X-ray
1.80A
)
1GJA
(X-ray
1.56A
)
1GJB
(X-ray
1.90A
)
1GJC
(X-ray
1.73A
)
1GJD
(X-ray
1.75A
)
1KDU
(NMR
-
)
1LMW
(X-ray
2.50A
)
1O3P
(X-ray
1.81A
)
1O5A
(X-ray
1.68A
)
1O5B
(X-ray
1.85A
)
1O5C
(X-ray
1.63A
)
1OWD
(X-ray
2.32A
)
1OWE
(X-ray
1.60A
)
1OWH
(X-ray
1.61A
)
1OWI
(X-ray
2.93A
)
1OWJ
(X-ray
3.10A
)
1OWK
(X-ray
2.80A
)
1SC8
(X-ray
2.40A
)
1SQA
(X-ray
2.00A
)
1SQO
(X-ray
1.84A
)
1SQT
(X-ray
1.90A
)
1U6Q
(X-ray
2.02A
)
1URK
(NMR
-
)
1VJ9
(X-ray
2.40A
)
1VJA
(X-ray
2.00A
)
1W0Z
(X-ray
1.90A
)
1W10
(X-ray
2.00A
)
1W11
(X-ray
2.00A
)
1W12
(X-ray
2.40A
)
1W13
(X-ray
2.00A
)
1W14
(X-ray
2.20A
)
2FD6
(X-ray
1.90A
)
2I9A
(X-ray
1.90A
)
2I9B
(X-ray
2.80A
)
2NWN
(X-ray
2.15A
)
2O8T
(X-ray
1.45A
)
2O8U
(X-ray
1.70A
)
2O8W
(X-ray
1.86A
)
2R2W
(X-ray
2.01A
)
2VIN
(X-ray
1.90A
)
2VIO
(X-ray
1.80A
)
2VIP
(X-ray
1.72A
)
2VIQ
(X-ray
2.00A
)
2VIV
(X-ray
1.72A
)
2VIW
(X-ray
2.05A
)
2VNT
(X-ray
2.20A
)
3BT1
(X-ray
2.80A
)
3BT2
(X-ray
2.50A
)
3IG6
(X-ray
1.83A
)
3KGP
(X-ray
2.35A
)
3KHV
(X-ray
2.35A
)
3KID
(X-ray
2.71A
)
3M61
(X-ray
1.68A
)
3MHW
(X-ray
1.45A
)
3MWI
(X-ray
2.03A
)
3OX7
(X-ray
1.58A
)
3OY5
(X-ray
2.31A
)
3OY6
(X-ray
2.31A
)
3PB1
(X-ray
2.30A
)
3QN7
(X-ray
1.90A
)
3U73
(X-ray
3.19A
)
4DVA
(X-ray
1.94A
)
4DW2
(X-ray
2.97A
)
4FU7
(X-ray
2.00A
)
4FU8
(X-ray
2.20A
)
4FU9
(X-ray
1.60A
)
4FUB
(X-ray
1.90A
)
4FUC
(X-ray
1.72A
)
4FUD
(X-ray
2.00A
)
4FUE
(X-ray
2.00A
)
4FUF
(X-ray
2.00A
)
4FUG
(X-ray
1.80A
)
4FUH
(X-ray
1.60A
)
4FUI
(X-ray
2.00A
)
4FUJ
(X-ray
2.05A
)
4GLY
(X-ray
1.52A
)
4H42
(X-ray
2.01A
)
4JK5
(X-ray
1.55A
)
4JK6
(X-ray
2.20A
)
4K24
(X-ray
4.50A
)
4MNV
(X-ray
1.80A
)
4MNW
(X-ray
1.49A
)
4MNX
(X-ray
1.85A
)
4MNY
(X-ray
1.70A
)
4OS1
(X-ray
2.20A
)
4OS2
(X-ray
1.79A
)
4OS4
(X-ray
2.00A
)
4OS5
(X-ray
2.26A
)
4OS6
(X-ray
1.75A
)
4OS7
(X-ray
2.00A
)
4X0W
(X-ray
2.10A
)
4X1N
(X-ray
1.80A
)
4X1P
(X-ray
1.60A
)
4X1Q
(X-ray
2.28A
)
4X1R
(X-ray
2.10A
)
4X1S
(X-ray
1.90A
)
4XSK
(X-ray
1.50A
)
4ZHL
(X-ray
2.06A
)
4ZHM
(X-ray
1.90A
)
4ZKN
(X-ray
1.36A
)
4ZKO
(X-ray
1.29A
)
4ZKR
(X-ray
1.36A
)
4ZKS
(X-ray
1.85A
)
5HGG
(X-ray
1.97A
)
5WXF
(X-ray
1.46A
)
5WXO
(X-ray
1.64A
)
5WXP
(X-ray
1.75A
)
5WXQ
(X-ray
1.79A
)
5WXR
(X-ray
1.75A
)
5WXS
(X-ray
2.30A
)
5WXT
(X-ray
2.10A
)
5XG4
(X-ray
3.00A
)
5YC6
(X-ray
1.18A
)
5YC7
(X-ray
2.00A
)
5Z1C
(X-ray
1.45A
)
5ZA7
(X-ray
1.70A
)
5ZA8
(X-ray
1.90A
)
5ZA9
(X-ray
1.62A
)
5ZAE
(X-ray
1.73A
)
5ZAF
(X-ray
1.65A
)
5ZAG
(X-ray
1.95A
)
5ZAH
(X-ray
2.98A
)
5ZAJ
(X-ray
1.65A
)
5ZC5
(X-ray
1.90A
)
6AG2
(X-ray
1.77A
)
6AG3
(X-ray
2.48A
)
6AG7
(X-ray
1.90A
)
6AG9
(X-ray
1.63A
)
6JYP
(X-ray
2.25A
)
6JYQ
(X-ray
1.75A
)
6L04
(X-ray
2.21A
)
6L05
(X-ray
2.49A
)
6NMB
(X-ray
2.30A
)
6XVD
(X-ray
1.40A
)
7DZD
(X-ray
2.00A
)
DBSNP
rs2227580
rs2227564
rs1050120
rs2227567
Subcellular location [CC]
Secreted {ECO:0000269|PubMed:24434139}.
Mouse PG classification
LPG
click here
to return to the previous page
