Gene Information
Gene NamePLAT
OrganismHomo sapiens (Human)
Gene Length562
Protein NamesTissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
Target Nametissue-type plasminogen activator
Target TypeNA
Gene Age544 ( ENSG00000104368 )
Evolutionary StageEukaryota
AlphaFoldDBP00750
Gene CardPLAT
Uniprot IDP00750
PfamPF00008; PF00039; PF00051; PF00089
In ASDyes
Allosteric Predictionyes (1.555498006)
Ortholog in AnimalsAlpaca_ PLAT ( ortholog_one2one )
GuineaPig_ PLAT ( ortholog_one2one )
Macaque_ PLAT ( ortholog_one2one )
Mouse_ Plat ( ortholog_one2one )
Pig_ PLAT ( ortholog_one2one )
Rat_ Plat ( ortholog_one2one )
Rabbit_ PLAT ( ortholog_one2one )
OhnologsPLAU, HABP2, HGFAC, F12
ParalogsOVCH1, PRSS48, PLGLB1, PLGLB2, PLG, TMPRSS12, GZMM, KLK15, PRSS37, PRSS27, PRSS33, PRSS57, PRSS50, KLK9
TissueNA
Tissue SpecificitySynthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1A5H  (X-ray  2.90A  )  1BDA  (X-ray  3.35A  )  1PK2  (NMR  -  )  1PML  (X-ray  2.38A  )  1RTF  (X-ray  2.30A  )  1TPG  (NMR  -  )  1TPK  (X-ray  2.40A  )  1TPM  (NMR  -  )  1TPN  (NMR  -  )  5BRR  (X-ray  3.16A  )  5ZLZ  (X-ray  3.58A  ) 
DBSNP rs8178733  rs8178747  rs8178748  rs2020921 
Subcellular location [CC]Secreted, extracellular space.
Mouse PG classificationHPG
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