| Gene Information | |
|---|---|
| Gene Name | PASD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 773 |
| Protein Names | Circadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000166049 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8IV76 |
| Gene Card | PASD1 |
| Uniprot ID | Q8IV76 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.095454428) |
| Ortholog in Animals | Alpaca_ PASD1 ( ortholog_one2many ) Dog_ PASD1 ( ortholog_one2one ) Macaque_ PASD1 ( ortholog_one2one ) Mouse_ Gm1141 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARNTL, ARNT, NPAS2, ARNT2, CLOCK, ARNTL2 |
| Tissue | testis |
| Tissue Specificity | Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151). Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151). {ECO:0000269|PubMed:15162151, ECO:0000269|PubMed:25936801}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs5924658 |
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}. |
| Mouse PG classification | NA |
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