| Gene Information | |
|---|---|
| Gene Name | PLAA |
| Organism | Homo sapiens (Human) |
| Gene Length | 795 |
| Protein Names | Phospholipase A-2-activating protein (PLA2P) (PLAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000137055 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y263 |
| Gene Card | PLAA |
| Uniprot ID | Q9Y263 |
| Pfam | PF09070; PF08324; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.571660374) |
| Ortholog in Animals | Alpaca_ PLAA ( ortholog_one2one ) Dog_ PLAA ( ortholog_one2one ) GuineaPig_ PLAA ( ortholog_one2one ) Macaque_ PLAA ( ortholog_one2one ) Mouse_ Plaa ( ortholog_one2one ) Pig_ PLAA ( ortholog_one2one ) Rat_ Plaa ( ortholog_one2one ) Rabbit_ PLAA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.006861(Chimpanzee);0.086977(Mouse);0.052107(Rat);0.051852(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K89 (NMR - ) 2K8A (NMR - ) 2K8B (NMR - ) 2K8C (NMR - ) 3EBB (X-ray 1.90A ) |
| DBSNP | rs747956857 rs1114167457 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28007986}. Cytoplasm {ECO:0000269|PubMed:27753622, ECO:0000269|PubMed:28007986}. Synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. {ECO:0000269|PubMed:27753622}. |
| Mouse PG classification | NA |
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