| Gene Information | |
|---|---|
| Gene Name | PICALM |
| Organism | Homo sapiens (Human) |
| Gene Length | 652 |
| Protein Names | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000073921 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13492 |
| Gene Card | PICALM |
| Uniprot ID | Q13492 |
| Pfam | PF07651 |
| In ASD | no |
| Allosteric Prediction | yes (0.124639345) |
| Ortholog in Animals | Alpaca_ PICALM ( ortholog_one2one ) Dog_ PICALM ( ortholog_one2one ) GuineaPig_ PICALM ( ortholog_one2one ) Macaque_ PICALM ( ortholog_one2one ) Mouse_ Picalm ( ortholog_one2one ) Pig_ PICALM ( ortholog_one2one ) Rat_ Picalm ( ortholog_one2one ) Rabbit_ PICALM ( ortholog_one2one ) |
| Ohnologs | SNAP91 |
| Paralogs | SNAP91 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined. {ECO:0000269|PubMed:8643484}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12800974 rs12222608 rs1043858 rs1043859 rs556337 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16262731}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:10436022}. Golgi apparatus {ECO:0000269|PubMed:10436022}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10436022}. Nucleus {ECO:0000269|PubMed:16491119}. Note=Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16491119}. |
| Mouse PG classification | NA |
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