Gene Information
Gene NamePSD4
OrganismHomo sapiens (Human)
Gene Length1056
Protein NamesPH and SEC7 domain-containing protein 4 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B) (Exchange factor for ARF6 B) (Pleckstrin homology and SEC7 domain-containing protein 4) (Telomeric of interleukin-1 cluster protein)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000125637 )
Evolutionary StageEukaryota
AlphaFoldDBQ8NDX1
Gene CardPSD4
Uniprot IDQ8NDX1
PfamPF15410; PF01369
In ASDno
Allosteric Predictionno (-1.210923545)
Ortholog in AnimalsAlpaca_ PSD4 ( ortholog_one2one )
Dog_ PSD4 ( ortholog_one2one )
GuineaPig_ PSD4 ( ortholog_one2one )
Macaque_ PSD4 ( ortholog_one2one )
Mouse_ Psd4 ( ortholog_one2one )
Rat_ Psd4 ( ortholog_one2one )
Rabbit_ PSD4 ( ortholog_one2one )
OhnologsPSD, PSD2, PSD3
ParalogsPSD2, PSD3, ARFGEF2, CYTH4, MON2, GBF1, ARFGEF1, PSD, FBXO8, CYTH1, IQSEC3, IQSEC1, CYTH2, IQSEC2, CYTH3
TissueNA
Tissue SpecificityWidely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood. {ECO:0000269|PubMed:12082148}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1562277  rs12472091  rs4849167  rs45487591  rs45574835 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:23603394}. Cell projection, ruffle membrane {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:23603394}. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions (PubMed:23603394). Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures (PubMed:12082148). Recruited to membranes via phosphatidylinositol phosphate-binding (Probable). {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:23603394, ECO:0000305|PubMed:12082148}.
Mouse PG classificationNA
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