| Gene Information | |
|---|---|
| Gene Name | POLA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1462 |
| Protein Names | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) |
| Target Name | dna polymerase alpha catalytic subunit |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000101868 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P09884 |
| Gene Card | POLA1 |
| Uniprot ID | P09884 |
| Pfam | PF12254; PF00136; PF03104; PF08996 |
| In ASD | no |
| Allosteric Prediction | yes (0.621554636) |
| Ortholog in Animals | Alpaca_ POLA1 ( ortholog_one2one ) Dog_ POLA1 ( ortholog_one2one ) GuineaPig_ POLA1 ( ortholog_one2one ) Macaque_ POLA1 ( ortholog_one2one ) Mouse_ Pola1 ( ortholog_one2one ) Pig_ POLA1 ( ortholog_one2one ) Rat_ Pola1 ( ortholog_one2one ) Rabbit_ POLA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | REV3L, NEXMIF, POLD1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.071429(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1K0P (NMR - ) 1K18 (NMR - ) 1N5G (NMR - ) 4Q5V (X-ray 2.52A ) 4QCL (X-ray 2.20A ) 4Y97 (X-ray 2.51A ) 5EXR (X-ray 3.60A ) 5IUD (X-ray 3.30A ) 6AS7 (X-ray 2.95A ) 7N2M (X-ray 2.90A ) 7OPL (EM 4.12A ) 7U5C (EM 4.60A ) 8D0B (EM 3.43A ) 8D0K (EM 4.27A ) |
| DBSNP | rs1569271378 rs1569271892 rs2230927 rs1569350993 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:27019227}. Cytoplasm, cytosol {ECO:0000269|PubMed:27019227}. Note=In the cytosol, colocalizes with RNA:DNA hybrids with a speckled pattern. {ECO:0000269|PubMed:27019227}. |
| Mouse PG classification | NA |
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