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Gene Information
Gene Name
MAPK14
Organism
Homo sapiens (Human)
Gene Length
360
Protein Names
Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)
Target Name
mitogen-activated protein kinases
Target Type
NA
Gene Age
645 ( ENSG00000112062 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
Q16539
Gene Card
MAPK14
Uniprot ID
Q16539
Pfam
PF00069
In ASD
yes
Allosteric Prediction
yes (2.052060495)
Ortholog in Animals
Alpaca_ MAPK14 ( ortholog_one2one )
Dog_ MAPK14 ( ortholog_one2one )
GuineaPig_ MAPK14 ( ortholog_one2one )
Macaque_ MAPK14 ( ortholog_one2one )
Mouse_ Mapk14 ( ortholog_one2one )
Pig_ MAPK14 ( ortholog_one2one )
Rat_ Mapk14 ( ortholog_one2one )
Ohnologs
MAPK11, MAPK12
Paralogs
MAPK8, MAPK10, MAPK1, MAPK6, MAPK12, MAPK13, SRPK1, SRPK3, MAPK4, NLK, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1
Tissue
NA
Tissue Specificity
Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.001844(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1A9U
(X-ray
2.50A
)
1BL6
(X-ray
2.50A
)
1BL7
(X-ray
2.50A
)
1BMK
(X-ray
2.40A
)
1DI9
(X-ray
2.60A
)
1IAN
(X-ray
2.00A
)
1KV1
(X-ray
2.50A
)
1KV2
(X-ray
2.80A
)
1M7Q
(X-ray
2.40A
)
1OUK
(X-ray
2.50A
)
1OUY
(X-ray
2.50A
)
1OVE
(X-ray
2.10A
)
1OZ1
(X-ray
2.10A
)
1R39
(X-ray
2.30A
)
1R3C
(X-ray
2.00A
)
1W7H
(X-ray
2.21A
)
1W82
(X-ray
2.20A
)
1W83
(X-ray
2.50A
)
1W84
(X-ray
2.20A
)
1WBN
(X-ray
2.40A
)
1WBO
(X-ray
2.16A
)
1WBS
(X-ray
1.80A
)
1WBT
(X-ray
2.00A
)
1WBV
(X-ray
2.00A
)
1WBW
(X-ray
2.41A
)
1WFC
(X-ray
2.30A
)
1YQJ
(X-ray
2.00A
)
1ZYJ
(X-ray
2.00A
)
1ZZ2
(X-ray
2.00A
)
1ZZL
(X-ray
2.00A
)
2BAJ
(X-ray
2.25A
)
2BAK
(X-ray
2.20A
)
2BAL
(X-ray
2.10A
)
2BAQ
(X-ray
2.80A
)
2FSL
(X-ray
1.70A
)
2FSM
(X-ray
1.86A
)
2FSO
(X-ray
1.83A
)
2FST
(X-ray
1.45A
)
2GFS
(X-ray
1.75A
)
2I0H
(X-ray
2.00A
)
2LGC
(NMR
-
)
2NPQ
(X-ray
1.80A
)
2OKR
(X-ray
2.00A
)
2ONL
(X-ray
4.00A
)
2QD9
(X-ray
1.70A
)
2RG5
(X-ray
2.40A
)
2RG6
(X-ray
1.72A
)
2Y8O
(X-ray
1.95A
)
2YIS
(X-ray
2.00A
)
2YIW
(X-ray
2.00A
)
2YIX
(X-ray
2.30A
)
2ZAZ
(X-ray
1.80A
)
2ZB0
(X-ray
2.10A
)
2ZB1
(X-ray
2.50A
)
3BV2
(X-ray
2.40A
)
3BV3
(X-ray
2.59A
)
3BX5
(X-ray
2.40A
)
3C5U
(X-ray
2.80A
)
3CTQ
(X-ray
1.95A
)
3D7Z
(X-ray
2.10A
)
3D83
(X-ray
1.90A
)
3DS6
(X-ray
2.90A
)
3DT1
(X-ray
2.80A
)
3E92
(X-ray
2.00A
)
3E93
(X-ray
2.00A
)
3FC1
(X-ray
2.40A
)
3FI4
(X-ray
2.20A
)
3FKL
(X-ray
2.00A
)
3FKN
(X-ray
2.00A
)
3FKO
(X-ray
2.00A
)
3FL4
(X-ray
1.80A
)
3FLN
(X-ray
1.90A
)
3FLQ
(X-ray
1.90A
)
3FLS
(X-ray
2.30A
)
3FLW
(X-ray
2.10A
)
3FLY
(X-ray
1.80A
)
3FLZ
(X-ray
2.23A
)
3FMH
(X-ray
1.90A
)
3FMJ
(X-ray
2.00A
)
3FMK
(X-ray
1.70A
)
3FML
(X-ray
2.10A
)
3FMM
(X-ray
2.00A
)
3FMN
(X-ray
1.90A
)
3FSF
(X-ray
2.10A
)
3FSK
(X-ray
2.00A
)
3GC7
(X-ray
1.80A
)
3GCP
(X-ray
2.25A
)
3GCQ
(X-ray
2.00A
)
3GCS
(X-ray
2.10A
)
3GCU
(X-ray
2.10A
)
3GCV
(X-ray
2.30A
)
3GFE
(X-ray
2.10A
)
3GI3
(X-ray
2.40A
)
3HA8
(X-ray
2.48A
)
3HEC
(X-ray
2.50A
)
3HEG
(X-ray
2.20A
)
3HL7
(X-ray
1.88A
)
3HLL
(X-ray
1.95A
)
3HP2
(X-ray
2.15A
)
3HP5
(X-ray
2.30A
)
3HRB
(X-ray
2.20A
)
3HUB
(X-ray
2.25A
)
3HUC
(X-ray
1.80A
)
3HV3
(X-ray
2.00A
)
3HV4
(X-ray
2.60A
)
3HV5
(X-ray
2.25A
)
3HV6
(X-ray
1.95A
)
3HV7
(X-ray
2.40A
)
3HVC
(X-ray
2.10A
)
3IPH
(X-ray
2.10A
)
3ITZ
(X-ray
2.25A
)
3IW5
(X-ray
2.50A
)
3IW6
(X-ray
2.10A
)
3IW7
(X-ray
2.40A
)
3IW8
(X-ray
2.00A
)
3K3I
(X-ray
1.70A
)
3K3J
(X-ray
2.00A
)
3KF7
(X-ray
2.00A
)
3KQ7
(X-ray
1.80A
)
3L8S
(X-ray
2.35A
)
3L8X
(X-ray
2.15A
)
3LFA
(X-ray
2.10A
)
3LFB
(X-ray
2.60A
)
3LFC
(X-ray
2.80A
)
3LFD
(X-ray
3.40A
)
3LFE
(X-ray
2.30A
)
3LFF
(X-ray
1.50A
)
3LHJ
(X-ray
3.31A
)
3MGY
(X-ray
2.10A
)
3MH0
(X-ray
2.00A
)
3MH1
(X-ray
2.20A
)
3MH2
(X-ray
2.30A
)
3MH3
(X-ray
2.20A
)
3MPA
(X-ray
2.10A
)
3MPT
(X-ray
1.89A
)
3MVL
(X-ray
2.80A
)
3MVM
(X-ray
2.00A
)
3MW1
(X-ray
2.80A
)
3NEW
(X-ray
2.51A
)
3NNU
(X-ray
2.40A
)
3NNV
(X-ray
2.10A
)
3NNW
(X-ray
1.89A
)
3NNX
(X-ray
2.28A
)
3NWW
(X-ray
2.09A
)
3O8P
(X-ray
2.10A
)
3O8T
(X-ray
2.00A
)
3O8U
(X-ray
2.10A
)
3OBG
(X-ray
2.80A
)
3OBJ
(X-ray
2.40A
)
3OC1
(X-ray
2.59A
)
3OCG
(X-ray
2.21A
)
3OD6
(X-ray
2.68A
)
3ODY
(X-ray
2.20A
)
3ODZ
(X-ray
2.30A
)
3OEF
(X-ray
1.60A
)
3PG3
(X-ray
2.00A
)
3QUD
(X-ray
2.00A
)
3QUE
(X-ray
2.70A
)
3RIN
(X-ray
2.20A
)
3ROC
(X-ray
1.70A
)
3S3I
(X-ray
1.80A
)
3S4Q
(X-ray
2.27A
)
3U8W
(X-ray
2.15A
)
3UVP
(X-ray
2.40A
)
3UVQ
(X-ray
2.20A
)
3UVR
(X-ray
2.10A
)
3ZS5
(X-ray
1.60A
)
3ZSG
(X-ray
1.89A
)
3ZSH
(X-ray
2.05A
)
3ZSI
(X-ray
2.40A
)
3ZYA
(X-ray
1.90A
)
4A9Y
(X-ray
2.20A
)
4AA0
(X-ray
1.80A
)
4AA4
(X-ray
2.30A
)
4AA5
(X-ray
2.38A
)
4AAC
(X-ray
2.50A
)
4DLI
(X-ray
1.91A
)
4DLJ
(X-ray
2.60A
)
4E5A
(X-ray
1.87A
)
4E5B
(X-ray
2.00A
)
4E6A
(X-ray
2.09A
)
4E6C
(X-ray
2.39A
)
4E8A
(X-ray
2.70A
)
4EH2
(X-ray
2.00A
)
4EH3
(X-ray
2.40A
)
4EH4
(X-ray
2.50A
)
4EH5
(X-ray
2.00A
)
4EH6
(X-ray
2.10A
)
4EH7
(X-ray
2.10A
)
4EH8
(X-ray
2.20A
)
4EH9
(X-ray
2.10A
)
4EHV
(X-ray
1.60A
)
4EWQ
(X-ray
2.10A
)
4F9W
(X-ray
2.00A
)
4F9Y
(X-ray
1.85A
)
4FA2
(X-ray
2.00A
)
4GEO
(X-ray
1.66A
)
4KIN
(X-ray
1.97A
)
4KIP
(X-ray
2.27A
)
4KIQ
(X-ray
2.50A
)
4L8M
(X-ray
2.10A
)
4R3C
(X-ray
2.06A
)
4ZTH
(X-ray
2.15A
)
5ETA
(X-ray
2.80A
)
5ETC
(X-ray
2.42A
)
5ETF
(X-ray
2.40A
)
5ETI
(X-ray
2.80A
)
5ML5
(X-ray
1.90A
)
5MTX
(X-ray
1.80A
)
5MTY
(X-ray
2.31A
)
5MZ3
(X-ray
2.15A
)
5N63
(X-ray
2.40A
)
5N64
(X-ray
2.40A
)
5N65
(X-ray
2.00A
)
5N66
(X-ray
2.40A
)
5N67
(X-ray
1.90A
)
5N68
(X-ray
1.85A
)
5O8U
(X-ray
2.00A
)
5O8V
(X-ray
2.00A
)
5OMG
(X-ray
2.00A
)
5OMH
(X-ray
2.50A
)
5TBE
(X-ray
2.44A
)
5TCO
(X-ray
2.10A
)
5WJJ
(X-ray
1.60A
)
5XYX
(X-ray
2.61A
)
5XYY
(X-ray
1.70A
)
6ANL
(X-ray
2.00A
)
6HWT
(X-ray
1.70A
)
6HWU
(X-ray
2.30A
)
6HWV
(X-ray
1.70A
)
6M95
(X-ray
1.80A
)
6M9L
(X-ray
2.45A
)
6OHD
(X-ray
2.50A
)
6QDZ
(X-ray
1.73A
)
6QE1
(X-ray
1.85A
)
6QYX
(X-ray
1.66A
)
6RFO
(X-ray
1.70A
)
6SFI
(X-ray
1.60A
)
6SFJ
(X-ray
1.95A
)
6SFK
(X-ray
1.80A
)
6SFO
(X-ray
1.75A
)
6TCA
(X-ray
3.70A
)
6ZQS
(X-ray
1.95A
)
6ZWP
(X-ray
1.90A
)
8A8M
(EM
4.00A
)
DBSNP
rs45496794
Subcellular location [CC]
Cytoplasm {ECO:0000269|PubMed:7535770}. Nucleus {ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:7535770}.
Mouse PG classification
NA
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