| Gene Information | |
|---|---|
| Gene Name | PKP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1192 |
| Protein Names | Plakophilin-4 (p0071) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000144283 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99569 |
| Gene Card | PKP4 |
| Uniprot ID | Q99569 |
| Pfam | PF00514 |
| In ASD | no |
| Allosteric Prediction | no (-0.999793822) |
| Ortholog in Animals | Alpaca_ PKP4 ( ortholog_one2one ) Dog_ PKP4 ( ortholog_one2one ) GuineaPig_ PKP4 ( ortholog_one2one ) Macaque_ PKP4 ( ortholog_one2one ) Mouse_ Pkp4 ( ortholog_one2one ) Pig_ PKP4 ( ortholog_one2one ) Rat_ Pkp4 ( ortholog_one2one ) Rabbit_ PKP4 ( ortholog_one2one ) |
| Ohnologs | CTNND1 |
| Paralogs | CTNND1, PKP1, PKP3, ARVCF, CTNND2, PKP2 |
| Tissue | NA |
| Tissue Specificity | Expressed in salivary glands (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). {ECO:0000269|PubMed:29034528, ECO:0000269|PubMed:30479852}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, desmosome {ECO:0000269|PubMed:17115030}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17115030}. Midbody {ECO:0000269|PubMed:17115030}. Cell membrane {ECO:0000269|PubMed:17115030}; Peripheral membrane protein {ECO:0000269|PubMed:17115030}. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells. |
| Mouse PG classification | NA |
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