| Gene Information | |
|---|---|
| Gene Name | PKP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 797 |
| Protein Names | Plakophilin-3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000184363 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y446 |
| Gene Card | PKP3 |
| Uniprot ID | Q9Y446 |
| Pfam | PF00514 |
| In ASD | no |
| Allosteric Prediction | no (-1.037522074) |
| Ortholog in Animals | GuineaPig_ PKP3 ( ortholog_one2one ) Macaque_ PKP3 ( ortholog_one2one ) Mouse_ Pkp3 ( ortholog_one2one ) Pig_ PKP3 ( ortholog_one2one ) Rat_ Pkp3 ( ortholog_one2one ) |
| Ohnologs | PKP2, PKP1 |
| Paralogs | CTNND1, PKP1, ARVCF, PKP4, CTNND2, PKP2 |
| Tissue | small.intestine |
| Tissue Specificity | Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors. {ECO:0000269|PubMed:24178805}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes. |
| Mouse PG classification | NA |
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