| Gene Information | |
|---|---|
| Gene Name | PKP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 747 |
| Protein Names | Plakophilin-1 (Band 6 protein) (B6P) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000081277 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13835 |
| Gene Card | PKP1 |
| Uniprot ID | Q13835 |
| Pfam | PF00514 |
| In ASD | no |
| Allosteric Prediction | no (-0.871162685) |
| Ortholog in Animals | Alpaca_ PKP1 ( ortholog_one2one ) Dog_ PKP1 ( ortholog_one2one ) GuineaPig_ PKP1 ( ortholog_one2one ) Macaque_ PKP1 ( ortholog_one2one ) Mouse_ Pkp1 ( ortholog_one2one ) Pig_ PKP1 ( ortholog_one2one ) Rat_ Pkp1 ( ortholog_one2one ) Rabbit_ PKP1 ( ortholog_one2one ) |
| Ohnologs | PKP2, PKP3 |
| Paralogs | CTNND1, PKP3, ARVCF, PKP4, CTNND2, PKP2 |
| Tissue | skin, tongue, zone.of.skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | [Isoform 1]: Expressed in stratified squamous, complex, glandular duct and bladder epithelia (at protein level). {ECO:0000269|PubMed:9369526}.; [Isoform 2]: Widely expressed (at protein level). {ECO:0000269|PubMed:9369526}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1XM9 (X-ray 2.80A ) |
| DBSNP | rs34626929 rs34704938 rs35507614 rs1626370 rs10920171 |
| Subcellular location [CC] | [Isoform 1]: Cell junction, desmosome {ECO:0000269|PubMed:9369526}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:9369526}.; Nucleus {ECO:0000269|PubMed:11790773}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |