| Gene Information | |
|---|---|
| Gene Name | PKN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 889 |
| Protein Names | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) |
| Target Name | protein kinase n3 |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000160447 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6P5Z2 |
| Gene Card | PKN3 |
| Uniprot ID | Q6P5Z2 |
| Pfam | PF02185; PF00069; PF00433 |
| In ASD | no |
| Allosteric Prediction | no (-0.394384157) |
| Ortholog in Animals | Alpaca_ PKN3 ( ortholog_one2one ) Dog_ PKN3 ( ortholog_one2one ) GuineaPig_ PKN3 ( ortholog_one2one ) Macaque_ PKN3 ( ortholog_one2one ) Mouse_ Pkn3 ( ortholog_one2one ) Pig_ PKN3 ( ortholog_one2one ) Rat_ Pkn3 ( ortholog_one2one ) |
| Ohnologs | PKN1, PKN2 |
| Paralogs | PKN1, PRKCE, PRKCH, PRKCZ, PRKCI, PKN2, PRKCG, PRKCA, PRKCB |
| Tissue | NA |
| Tissue Specificity | Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues. {ECO:0000269|PubMed:10441506}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs56251280 rs12932 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10441506}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10441506}. Note=Nuclear and perinuclear Golgi region. |
| Mouse PG classification | NA |
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