Gene Information
Gene NamePKN1
OrganismHomo sapiens (Human)
Gene Length942
Protein NamesSerine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
Target Nameserine/threonine-protein kinase n1
Target TypeNA
Gene Age680 ( ENSG00000123143 )
Evolutionary StageVertebrata
AlphaFoldDBQ16512
Gene CardPKN1
Uniprot IDQ16512
PfamPF02185; PF00069; PF00433
In ASDno
Allosteric Predictionyes (0.997946334)
Ortholog in AnimalsAlpaca_ PKN1 ( ortholog_one2one )
Dog_ PKN1 ( ortholog_one2one )
GuineaPig_ PKN1 ( ortholog_one2one )
Macaque_ PKN1 ( ortholog_one2one )
Mouse_ Pkn1 ( ortholog_one2one )
Pig_ PKN1 ( ortholog_one2one )
Rat_ Pkn1 ( ortholog_one2one )
OhnologsPKN2, PKN3
ParalogsPKN3, PRKCE, PRKCH, PRKCZ, PRKCI, PKN2, PRKCG, PRKCA, PRKCB
TissueNA
Tissue SpecificityFound ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. {ECO:0000269|PubMed:21754995}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CXZ  (X-ray  2.20A  )  1URF  (NMR  -  )  2RMK  (NMR  -  )  4NKG  (X-ray  2.90A  )  4OTD  (X-ray  2.00A  )  4OTG  (X-ray  2.60A  )  4OTH  (X-ray  1.80A  )  4OTI  (X-ray  1.93A  ) 
DBSNP rs267605306  rs1287763348  rs35132656  rs56273055  rs34309238  rs35416389  rs2230539  rs10846 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:9478917}. Nucleus {ECO:0000269|PubMed:12514133}. Endosome {ECO:0000269|PubMed:9478917}. Cell membrane {ECO:0000250|UniProtKB:Q63433};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q63433}. Cleavage furrow {ECO:0000269|PubMed:17332740}. Midbody {ECO:0000269|PubMed:17332740}. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. {ECO:0000250|UniProtKB:Q63433, ECO:0000269|PubMed:17332740}.
Mouse PG classificationNA
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