Gene Information
Gene NamePKN
OrganismHomo sapiens (Human)
Gene Length942
Protein NamesSerine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ16512
Gene CardPKN1
Uniprot IDQ16512
PfamPF02185; PF00069; PF00433
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityFound ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells. {ECO:0000269|PubMed:21754995}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CXZ  (X-ray  2.20A  )  1URF  (NMR  -  )  2RMK  (NMR  -  )  4NKG  (X-ray  2.90A  )  4OTD  (X-ray  2.00A  )  4OTG  (X-ray  2.60A  )  4OTH  (X-ray  1.80A  )  4OTI  (X-ray  1.93A  ) 
DBSNP rs267605306  rs1287763348  rs35132656  rs56273055  rs34309238  rs35416389  rs2230539  rs10846 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:9478917}. Nucleus {ECO:0000269|PubMed:12514133}. Endosome {ECO:0000269|PubMed:9478917}. Cell membrane {ECO:0000250|UniProtKB:Q63433};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q63433}. Cleavage furrow {ECO:0000269|PubMed:17332740}. Midbody {ECO:0000269|PubMed:17332740}. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis. {ECO:0000250|UniProtKB:Q63433, ECO:0000269|PubMed:17332740}.
Mouse PG classificationNA
click here to return to the previous page