| Gene Information | |
|---|---|
| Gene Name | TNFRSF6B |
| Organism | Homo sapiens (Human) |
| Gene Length | 300 |
| Protein Names | Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 78 ( ENSG00000243509 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | O95407 |
| Gene Card | TNFRSF6B |
| Uniprot ID | O95407 |
| Pfam | PF00020 |
| In ASD | no |
| Allosteric Prediction | no (-0.358372987) |
| Ortholog in Animals | Dog_ TNFRSF6B ( ortholog_one2one ) Macaque_ TNFRSF6B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3K51 (X-ray 2.45A ) 3MHD (X-ray 2.90A ) 3MI8 (X-ray 2.95A ) 4J6G (X-ray 2.40A ) 4KGG (X-ray 2.78A ) 4KGQ (X-ray 2.27A ) 4MSV (X-ray 2.50A ) 5L36 (X-ray 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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