| Gene Information | |
|---|---|
| Gene Name | PKM |
| Organism | Homo sapiens (Human) |
| Gene Length | 531 |
| Protein Names | Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58) |
| Target Name | pyruvate kinase m2 |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000067225 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P14618 |
| Gene Card | PKM |
| Uniprot ID | P14618 |
| Pfam | PF00224; PF02887 |
| In ASD | yes |
| Allosteric Prediction | yes (1.863908179) |
| Ortholog in Animals | Alpaca_ PKM ( ortholog_one2one ) Dog_ PARP6 ( ortholog_one2many ) GuineaPig_ PKM ( ortholog_one2one ) Mouse_ Pkm ( ortholog_one2one ) Pig_ PKM ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PKLR |
| Tissue | NA |
| Tissue Specificity | [Isoform M2]: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. {ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:18337823}.; [Isoform M1]: Expressed in adult tissues (PubMed:18337823). Not expressed in tumor cells (PubMed:18337823). {ECO:0000269|PubMed:18337823}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1T5A (X-ray 2.80A ) 1ZJH (X-ray 2.20A ) 3BJF (X-ray 2.03A ) 3BJT (X-ray 2.50A ) 3G2G (X-ray 2.00A ) 3GQY (X-ray 1.85A ) 3GR4 (X-ray 1.60A ) 3H6O (X-ray 2.00A ) 3ME3 (X-ray 1.95A ) 3SRD (X-ray 2.90A ) 3SRF (X-ray 2.84A ) 3SRH (X-ray 2.60A ) 3U2Z (X-ray 2.10A ) 4B2D (X-ray 2.30A ) 4FXF (X-ray 2.55A ) 4FXJ (X-ray 2.90A ) 4G1N (X-ray 2.30A ) 4JPG (X-ray 2.33A ) 4QG6 (X-ray 3.21A ) 4QG8 (X-ray 2.30A ) 4QG9 (X-ray 2.38A ) 4QGC (X-ray 2.30A ) 4RPP (X-ray 2.58A ) 4WJ8 (X-ray 2.87A ) 4YJ5 (X-ray 2.41A ) 5X0I (X-ray 2.64A ) 5X1V (X-ray 2.10A ) 5X1W (X-ray 3.00A ) 6B6U (X-ray 1.35A ) 6GG3 (X-ray 3.72A ) 6GG4 (X-ray 2.46A ) 6GG5 (X-ray 3.20A ) 6GG6 (X-ray 2.96A ) 6JFB (X-ray 2.12A ) 6NU1 (X-ray 2.25A ) 6NU5 (X-ray 1.60A ) 6NUB (X-ray 1.70A ) 6TTF (EM 3.20A ) 6TTH (EM 2.60A ) 6TTI (EM 2.50A ) 6TTQ (EM 2.70A ) 6V74 (X-ray 2.32A ) 6V75 (X-ray 2.85A ) 6V76 (X-ray 2.75A ) 6WP3 (X-ray 1.84A ) 6WP4 (X-ray 1.90A ) 6WP5 (X-ray 2.17A ) 6WP6 (X-ray 2.45A ) 7L21 (X-ray 2.29A ) |
| DBSNP | rs17853396 |
| Subcellular location [CC] | [Isoform M2]: Cytoplasm {ECO:0000269|PubMed:25263439, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:22901803, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900, ECO:0000269|PubMed:32268273}. Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylation by EP300 (PubMed:24120661). Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis (PubMed:26787900). {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:22056988, ECO:0000269|PubMed:24120661, ECO:0000269|PubMed:26787900}.; [Isoform M1]: Cytoplasm {ECO:0000305}. |
| Mouse PG classification | NA |
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