| Gene Information | |
|---|---|
| Gene Name | PKLR |
| Organism | Homo sapiens (Human) |
| Gene Length | 574 |
| Protein Names | Pyruvate kinase PKLR (EC 2.7.1.40) (Pyruvate kinase 1) (Pyruvate kinase isozymes L/R) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) |
| Target Name | pyruvate kinase pklr |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000143627 ) 3 ( ENSG00000262785 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P30613 |
| Gene Card | PKLR |
| Uniprot ID | P30613 |
| Pfam | PF00224; PF02887 |
| In ASD | yes |
| Allosteric Prediction | yes (1.193723722) |
| Ortholog in Animals | Alpaca_ PKLR ( ortholog_one2one ) Dog_ PKLR ( ortholog_one2one ) GuineaPig_ PKLR ( ortholog_one2one ) Macaque_ PKLR ( ortholog_one2one ) Mouse_ Pklr ( ortholog_one2one ) Pig_ PKLR ( ortholog_one2one ) Rat_ Pklr ( ortholog_one2one ) Rabbit_ PKLR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PKM |
| Tissue | kidney, liver, small.intestine |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2VGB (X-ray 2.73A ) 2VGF (X-ray 2.75A ) 2VGG (X-ray 2.74A ) 2VGI (X-ray 2.87A ) 4IMA (X-ray 1.95A ) 4IP7 (X-ray 1.80A ) 6NN4 (X-ray 2.15A ) 6NN5 (X-ray 2.26A ) 6NN7 (X-ray 2.32A ) 6NN8 (X-ray 2.42A ) 7QDN (X-ray 1.70A ) |
| DBSNP | rs118204087 rs1484388413 rs750857114 rs918627824 rs118204089 rs574051756 rs780192373 rs1239029841 rs118204083 rs757359024 rs200572803 rs1253386414 rs147659527 rs747549978 rs1352610988 rs766353400 rs981505482 rs549295725 rs138476691 rs773893686 rs773626254 rs1167329263 rs747097960 rs1227427396 rs1240481888 rs779152555 rs138871700 rs1376070580 rs765903674 rs981579065 rs74315362 rs147034239 rs1403323591 rs1168490341 rs776594413 rs1035640530 rs118204084 rs768002493 rs1023689443 rs762591322 rs755522396 rs752034960 rs750540943 rs759466273 rs118204085 rs116100695 rs369183199 rs200133000 rs141560532 rs551883218 rs758327704 rs185753709 rs8177988 rs113403872 rs758278200 rs201255024 rs370316462 rs61755431 |
| Subcellular location [CC] | NA |
| Mouse PG classification | HPG |
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