| Gene Information | |
|---|---|
| Gene Name | PKD1L2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2459 |
| Protein Names | Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000166473 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z442 |
| Gene Card | PKD1L2 |
| Uniprot ID | Q7Z442 |
| Pfam | PF02140; PF01825; PF00059; PF08016; PF01477; PF20519; PF02010 |
| In ASD | no |
| Allosteric Prediction | no (-0.128754499) |
| Ortholog in Animals | Mouse_ Pkd1l2 ( ortholog_one2one ) Pig_ PKD1L2 ( ortholog_one2one ) Rat_ Pkd1l2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PKDREJ, PKD2L2, DENND5B, DENND5A, PKD2L1, LOXHD1, PKD1L3, PKD1L1, PKD1, PKD2 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested including brain, placenta, mammary gland, testis, lung and liver. Highest expression in skeletal muscle. Isoform 2 is expressed in heart and kidney. {ECO:0000269|PubMed:12782129}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9924530 rs9924371 rs9934272 rs7191351 rs7185774 rs35528333 rs35970134 rs36099350 rs8060294 rs12933806 rs34719852 rs6564838 rs6420424 rs11150370 rs9937169 rs7194871 rs9934856 rs7205673 rs13339342 rs4889261 rs9935113 rs1869349 rs12596941 rs745211 rs34504526 rs35292101 rs12597040 rs12931227 rs12931217 rs16954794 rs734824 rs1453324 rs1453325 rs9938333 rs1453326 rs8050904 rs16954775 rs9921827 rs9921748 rs7192948 rs7194136 rs35941327 rs4889244 rs12918619 rs16954722 rs7206183 rs16954717 rs8050204 rs4889241 rs4889238 rs8054182 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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