| Gene Information | |
|---|---|
| Gene Name | DISC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 854 |
| Protein Names | Disrupted in schizophrenia 1 protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000162946 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NRI5 |
| Gene Card | DISC1 |
| Uniprot ID | Q9NRI5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.065805953) |
| Ortholog in Animals | Alpaca_ DISC1 ( ortholog_one2one ) Dog_ DISC1 ( ortholog_one2one ) GuineaPig_ DISC1 ( ortholog_one2one ) Macaque_ DISC1 ( ortholog_one2one ) Mouse_ Disc1 ( ortholog_one2one ) Pig_ DISC1 ( ortholog_one2one ) Rat_ Disc1 ( ortholog_one2one ) Rabbit_ DISC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | pineal.gland |
| Tissue Specificity | Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. {ECO:0000269|PubMed:16510495}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.008(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5V4B (X-ray 2.60A ) |
| DBSNP | rs3738400 rs56020408 rs3738401 rs55795950 rs34622148 rs56229136 rs6675281 rs821616 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12506198, ECO:0000269|PubMed:15797709}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14962739, ECO:0000269|PubMed:15797709}. Mitochondrion {ECO:0000269|PubMed:12506198, ECO:0000269|PubMed:15797709}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12812986, ECO:0000269|PubMed:18955030}. Postsynaptic density {ECO:0000250|UniProtKB:Q811T9}. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria (PubMed:12506198, PubMed:15797709). Colocalizes with PCNT at the centrosome (PubMed:18955030). {ECO:0000250|UniProtKB:Q811T9, ECO:0000269|PubMed:12506198, ECO:0000269|PubMed:15797709, ECO:0000269|PubMed:18955030}. |
| Mouse PG classification | LPG |
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