| Gene Information | |
|---|---|
| Gene Name | PPP6C |
| Organism | Homo sapiens (Human) |
| Gene Length | 305 |
| Protein Names | Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000119414 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00743 |
| Gene Card | PPP6C |
| Uniprot ID | O00743 |
| Pfam | PF00149 |
| In ASD | yes |
| Allosteric Prediction | yes (0.312974774) |
| Ortholog in Animals | Alpaca_ PPP6C ( ortholog_one2one ) Dog_ PPP6C ( ortholog_one2many ) GuineaPig_ PPP6C ( ortholog_one2one ) Macaque_ PPP6C ( ortholog_one2one ) Mouse_ Ppp6c ( ortholog_one2one ) Pig_ PPP6C ( ortholog_one2one ) Rat_ Ppp6c ( ortholog_one2one ) Rabbit_ PPP6C ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PPP3CC, PPP3CB, PPP5C, PPP2CB, PPP2CA, PPEF2, PPP4C, PPP3CA, PPEF1, PPP1CA, PPP1CC, PPP1CB |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:9013334}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.017391(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:29053956}. Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:17568194}. |
| Mouse PG classification | NA |
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