| Gene Information | |
|---|---|
| Gene Name | PRDX6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 224 |
| Protein Names | Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12) |
| Target Name | peroxiredoxin-6 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000117592 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P30041 |
| Gene Card | PRDX6 |
| Uniprot ID | P30041 |
| Pfam | PF10417; PF00578 |
| In ASD | no |
| Allosteric Prediction | yes (0.469726063) |
| Ortholog in Animals | Alpaca_ PRDX6 ( ortholog_one2one ) Dog_ PRDX6 ( ortholog_one2one ) GuineaPig_ PRDX6 ( ortholog_one2one ) Macaque_ PRDX6 ( ortholog_one2one ) Mouse_ Prdx6 ( ortholog_one2many ) Mouse_ Prdx6b ( ortholog_one2many ) Pig_ PRDX6 ( ortholog_one2one ) Rat_ Prdx6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRDX4, PRDX3, PRDX1, PRDX2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PRX (X-ray 2.00A ) 5B6M (X-ray 2.50A ) 5B6N (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:9497358}. Lysosome {ECO:0000250|UniProtKB:O35244}. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250|UniProtKB:O35244}. |
| Mouse PG classification | NA |
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