| Gene Information | |
|---|---|
| Gene Name | PKACA |
| Organism | Homo sapiens (Human) |
| Gene Length | 351 |
| Protein Names | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P17612 |
| Gene Card | PRKACA |
| Uniprot ID | P17612 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is ubiquitous. Isoform 2 is sperm-specific and is enriched in pachytene spermatocytes but is not detected in round spermatids. {ECO:0000269|PubMed:10906071, ECO:0000269|PubMed:21812984}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2GU8 (X-ray 2.20A ) 3AGL (X-ray 2.10A ) 3AGM (X-ray 2.00A ) 3AMA (X-ray 1.75A ) 3AMB (X-ray 2.25A ) 3L9L (X-ray 2.00A ) 3L9M (X-ray 1.90A ) 3L9N (X-ray 2.00A ) 3MVJ (X-ray 2.49A ) 3NX8 (X-ray 2.00A ) 3OOG (X-ray 2.00A ) 3OVV (X-ray 1.58A ) 3OWP (X-ray 1.88A ) 3OXT (X-ray 2.20A ) 3P0M (X-ray 2.03A ) 3POO (X-ray 1.60A ) 3VQH (X-ray 1.95A ) 4AE6 (X-ray 2.10A ) 4AE9 (X-ray 2.30A ) 4UJ1 (X-ray 1.77A ) 4UJ2 (X-ray 2.02A ) 4UJ9 (X-ray 1.87A ) 4UJA (X-ray 1.93A ) 4UJB (X-ray 1.95A ) 4WB5 (X-ray 1.64A ) 4WB6 (X-ray 2.10A ) 4WB7 (X-ray 1.90A ) 4WB8 (X-ray 1.55A ) 5BX6 (X-ray 1.89A ) 5BX7 (X-ray 1.89A ) 5IZF (X-ray 2.10A ) 5IZJ (X-ray 1.85A ) 5J5X (X-ray 2.60A ) 5N23 (X-ray 2.09A ) 5UZK (X-ray 2.30A ) 6BYR (X-ray 3.66A ) 6BYS (X-ray 4.75A ) 6C0U (X-ray 2.65A ) 6FRX (X-ray 1.88A ) 6NO7 (X-ray 3.55A ) 6QJ7 (X-ray 1.69A ) 6WJF (EM 7.50A ) 6WJG (EM 6.20A ) |
| DBSNP | rs56029020 rs56085217 rs386352352 rs35635531 |
| Subcellular location [CC] | Cytoplasm. Cell membrane. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490). {ECO:0000250, ECO:0000269|PubMed:21085490}.; [Isoform 2]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:10906071}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P05132}. Note=Expressed in the midpiece region of the sperm flagellum (PubMed:10906071). Colocalizes with MROH2B and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (By similarity). {ECO:0000250|UniProtKB:P05132, ECO:0000269|PubMed:10906071}. |
| Mouse PG classification | NA |
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