| Gene Information | |
|---|---|
| Gene Name | PIWIL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 861 |
| Protein Names | Piwi-like protein 1 (EC 3.1.26.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000125207 ) 3 ( ENSG00000275051 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96J94 |
| Gene Card | PIWIL1 |
| Uniprot ID | Q96J94 |
| Pfam | PF08699; PF05831; PF02170; PF02171 |
| In ASD | no |
| Allosteric Prediction | no (-0.588078913) |
| Ortholog in Animals | Alpaca_ PIWIL1 ( ortholog_one2one ) Dog_ PIWIL1 ( ortholog_one2one ) GuineaPig_ PIWIL1 ( ortholog_one2one ) Macaque_ PIWIL1 ( ortholog_one2one ) Mouse_ Piwil1 ( ortholog_one2one ) Pig_ PIWIL1 ( ortholog_one2one ) Rat_ Piwil1 ( ortholog_one2one ) Rabbit_ PIWIL1 ( ortholog_one2one ) |
| Ohnologs | PIWIL3, PIWIL4 |
| Paralogs | PIWIL3, PIWIL4, PIWIL2 |
| Tissue | testis |
| Tissue Specificity | Expressed in spermatocytes and spermatids. Also detected in prostate cancer (at protein level). Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3: Ubiquitously expressed, and specifically in CD34(+) hematopoietic progenitor cells but not in more differentiated cells. {ECO:0000269|PubMed:11154219, ECO:0000269|PubMed:12037681, ECO:0000269|PubMed:12906857, ECO:0000269|PubMed:23436708}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L5C (NMR - ) 2L5D (NMR - ) 3O3I (X-ray 2.80A ) 3O6E (X-ray 2.90A ) 3O7V (X-ray 2.10A ) 6PI7 (X-ray 2.80A ) |
| DBSNP | rs17856812 rs1106042 rs17852568 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9JMB7}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body. {ECO:0000250|UniProtKB:Q9JMB7}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |