| Gene Information | |
|---|---|
| Gene Name | PIWI |
| Organism | Homo sapiens (Human) |
| Gene Length | 852 |
| Protein Names | Piwi-like protein 4 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q7Z3Z4 |
| Gene Card | PIWIL4 |
| Uniprot ID | Q7Z3Z4 |
| Pfam | PF02170; PF02171 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:25038252, PubMed:17544373, PubMed:28025795, PubMed:28711973, PubMed:22483988). Detected in retina, retinal pigment epithelia cells (RPE) (at protein level) (PubMed:28025795). {ECO:0000269|PubMed:17544373, ECO:0000269|PubMed:22483988, ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795, ECO:0000269|PubMed:28711973}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12276921 rs12272255 rs11020845 rs57607909 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Cytoplasm {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8CGT6}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |