| Gene Information | |
|---|---|
| Gene Name | PITX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000164093 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99697 |
| Gene Card | PITX2 |
| Uniprot ID | Q99697 |
| Pfam | PF00046; PF03826 |
| In ASD | no |
| Allosteric Prediction | no (-0.309280774) |
| Ortholog in Animals | Alpaca_ PITX2 ( ortholog_one2one ) Dog_ PITX2 ( ortholog_one2one ) Macaque_ PITX2 ( ortholog_one2one ) Pig_ PITX2 ( ortholog_one2one ) Rabbit_ PITX2 ( ortholog_one2one ) |
| Ohnologs | PITX1, PITX3 |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | placenta |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L7F (NMR - ) 2L7M (NMR - ) 2LKX (NMR - ) |
| DBSNP | rs104893857 rs104893862 rs1057519484 rs104893858 rs104893861 rs121909249 rs121909248 rs387906810 rs104893859 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | HPG |
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