| Gene Information | |
|---|---|
| Gene Name | PLOD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 737 |
| Protein Names | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2) |
| Target Name | procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000152952 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O00469 |
| Gene Card | PLOD2 |
| Uniprot ID | O00469 |
| Pfam | PF03171 |
| In ASD | no |
| Allosteric Prediction | no (-0.120683688) |
| Ortholog in Animals | Alpaca_ PLOD2 ( ortholog_one2one ) Dog_ PLOD2 ( ortholog_one2one ) GuineaPig_ PLOD2 ( ortholog_one2one ) Macaque_ PLOD2 ( ortholog_one2one ) Mouse_ Plod2 ( ortholog_one2one ) Pig_ PLOD2 ( ortholog_one2one ) Rat_ Plod2 ( ortholog_one2one ) Rabbit_ PLOD2 ( ortholog_one2one ) |
| Ohnologs | PLOD3, PLOD1 |
| Paralogs | PLOD1, PLOD3, CERCAM, COLGALT2, COLGALT1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in pancreas and muscle. Isoform 1 and isoform 2 are expressed in the majority of the examined cell types. Isoform 2 is specifically expressed in skin, lung, dura and aorta. {ECO:0000269|PubMed:10372558}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs533478450 rs121434461 rs762788421 rs121434460 rs121434459 rs763670371 |
| Subcellular location [CC] | Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. |
| Mouse PG classification | NA |
| click here to return to the previous page | |