| Gene Information | |
|---|---|
| Gene Name | PIR |
| Organism | Homo sapiens (Human) |
| Gene Length | 290 |
| Protein Names | Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000087842 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O00625 |
| Gene Card | PIR |
| Uniprot ID | O00625 |
| Pfam | PF02678; PF05726 |
| In ASD | no |
| Allosteric Prediction | no (-1.103770741) |
| Ortholog in Animals | Alpaca_ PIR ( ortholog_one2one ) Dog_ PIR ( ortholog_one2one ) GuineaPig_ PIR ( ortholog_one2one ) Macaque_ PIR ( ortholog_one2one ) Mouse_ Pir ( ortholog_one2one ) Pig_ PIR ( ortholog_one2one ) Rat_ Pir ( ortholog_one2one ) Rabbit_ PIR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1J1L (X-ray 2.10A ) 3ACL (X-ray 2.35A ) 4ERO (X-ray 2.65A ) 4EWA (X-ray 2.47A ) 4EWD (X-ray 2.15A ) 4EWE (X-ray 1.56A ) 4GUL (X-ray 1.80A ) 4HLT (X-ray 1.70A ) 5JCT (X-ray 1.73A ) 6H1H (X-ray 1.54A ) 6H1I (X-ray 1.69A ) 6N0J (X-ray 1.79A ) 6N0K (X-ray 1.46A ) |
| DBSNP | rs34104000 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}. Cytoplasm {ECO:0000269|PubMed:20089166}. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}. |
| Mouse PG classification | NA |
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