| Gene Information | |
|---|---|
| Gene Name | PIP5K1C |
| Organism | Homo sapiens (Human) |
| Gene Length | 668 |
| Protein Names | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000186111 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60331 |
| Gene Card | PIP5K1C |
| Uniprot ID | O60331 |
| Pfam | PF01504 |
| In ASD | no |
| Allosteric Prediction | yes (0.112542335) |
| Ortholog in Animals | Alpaca_ PIP5K1C ( ortholog_one2one ) Dog_ PIP5K1C ( ortholog_one2one ) GuineaPig_ PIP5K1C ( ortholog_one2one ) Macaque_ PIP5K1C ( ortholog_one2one ) Mouse_ Pip5k1c ( ortholog_one2one ) Pig_ PIP5K1C ( ortholog_one2one ) Rat_ Pip5k1c ( ortholog_one2one ) |
| Ohnologs | PIP5K1B, PIP5K1A |
| Paralogs | PIP4K2C, PIP5K1A, PIP5KL1, PIP5K1B, PIP4K2B, PIP4K2A |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Isoform 1 is strongly expressed in brain and also detected in heart and lung. {ECO:0000269|PubMed:19548880}.; [Isoform 2]: Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney. {ECO:0000269|PubMed:19548880}.; [Isoform 3]: Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney. {ECO:0000269|PubMed:19548880}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2G35 (NMR - ) 3H1Z (X-ray 1.83A ) 3H85 (X-ray 2.60A ) |
| DBSNP | rs121908315 |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q5I6B8}. Endomembrane system {ECO:0000250|UniProtKB:Q5I6B8}. Cytoplasm {ECO:0000250|UniProtKB:O70161}. Cell junction, focal adhesion {ECO:0000269|PubMed:12422219}. Cell junction, adherens junction {ECO:0000269|PubMed:17261850}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q5I6B8}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70161}. Cell projection, uropodium {ECO:0000250|UniProtKB:O70161}. Note=Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures.; [Isoform 2]: Cytoplasm. Nucleus. |
| Mouse PG classification | NA |
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