| Gene Information | |
|---|---|
| Gene Name | PIP5K1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 562 |
| Protein Names | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) |
| Target Name | ptdins(4)p-5-kinase 1 alpha |
| Target Type | Literature-reported target |
| Gene Age | 987 ( ENSG00000143398 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99755 |
| Gene Card | PIP5K1A |
| Uniprot ID | Q99755 |
| Pfam | PF01504 |
| In ASD | no |
| Allosteric Prediction | no (-0.450251511) |
| Ortholog in Animals | Alpaca_ PIP5K1A ( ortholog_one2one ) Dog_ PIP5K1A ( ortholog_one2one ) GuineaPig_ PIP5K1A ( ortholog_one2one ) Macaque_ PIP5K1A ( ortholog_one2one ) Mouse_ Pip5k1a ( ortholog_one2one ) Pig_ PIP5K1A ( ortholog_one2one ) Rat_ Pip5k1a ( ortholog_one2one ) Rabbit_ PIP5K1A ( ortholog_one2one ) |
| Ohnologs | PIP5K1B, PIP5K1C |
| Paralogs | PIP4K2C, PIP5KL1, PIP5K1B, PIP4K2B, PIP5K1C, PIP4K2A |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver. {ECO:0000269|PubMed:8955136}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P70182}. Cytoplasm {ECO:0000250|UniProtKB:P70182}. Nucleus {ECO:0000269|PubMed:15157668}. Nucleus speckle {ECO:0000269|PubMed:18288197}. Cell projection, ruffle {ECO:0000269|PubMed:20660631}. Cell projection, lamellipodium {ECO:0000269|PubMed:15157668}. Note=Colocalizes with RAC1 at actin-rich membrane ruffles (PubMed:20660631). Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs (PubMed:18288197). {ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:20660631}. |
| Mouse PG classification | NA |
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