| Gene Information | |
|---|---|
| Gene Name | RP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Protein XRP2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000102218 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75695 |
| Gene Card | RP2 |
| Uniprot ID | O75695 |
| Pfam | PF07986 |
| In ASD | no |
| Allosteric Prediction | no (-0.796784932) |
| Ortholog in Animals | Alpaca_ RP2 ( ortholog_one2one ) Dog_ RP2 ( ortholog_one2one ) GuineaPig_ RP2 ( ortholog_one2one ) Macaque_ RP2 ( ortholog_one2one ) Mouse_ Rp2 ( ortholog_one2one ) Pig_ RP2 ( ortholog_one2one ) Rat_ Rp2 ( ortholog_one2one ) Rabbit_ RP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level). {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528, ECO:0000269|PubMed:18376416}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BX6 (X-ray 2.10A ) 3BH6 (X-ray 2.60A ) 3BH7 (X-ray 1.90A ) |
| DBSNP | rs137852284 rs1556318633 rs28933687 rs28933687 rs3126141 rs1805147 rs1805148 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528}; Lipid-anchor {ECO:0000269|PubMed:10942419}; Cytoplasmic side {ECO:0000269|PubMed:10942419}. Cell projection, cilium {ECO:0000269|PubMed:20106869}. Note=Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. {ECO:0000269|PubMed:12417528}. |
| Mouse PG classification | HPG |
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