| Gene Information | |
|---|---|
| Gene Name | PIP4K2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000150867 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P48426 |
| Gene Card | PIP4K2A |
| Uniprot ID | P48426 |
| Pfam | PF01504 |
| In ASD | no |
| Allosteric Prediction | no (-0.088728688) |
| Ortholog in Animals | Alpaca_ PIP4K2A ( ortholog_one2one ) Dog_ PIP4K2A ( ortholog_one2one ) GuineaPig_ PIP4K2A ( ortholog_one2one ) Macaque_ PIP4K2A ( ortholog_one2one ) Mouse_ Pip4k2a ( ortholog_one2one ) Pig_ PIP4K2A ( ortholog_one2one ) Rat_ AABR07028769.1 ( ortholog_one2one ) Rabbit_ PIP4K2A ( ortholog_one2one ) |
| Ohnologs | PIP4K2C |
| Paralogs | PIP4K2C, PIP5K1A, PIP5KL1, PIP5K1B, PIP4K2B, PIP5K1C |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO:0000269|PubMed:7639683, ECO:0000269|PubMed:7852364}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YBX (X-ray 2.56A ) 6OSP (X-ray 2.21A ) 6UX9 (X-ray 1.71A ) 6YM3 (X-ray 2.05A ) 6YM4 (X-ray 1.95A ) 6YM5 (X-ray 2.50A ) 7N6Z (X-ray 2.20A ) 7N71 (X-ray 2.50A ) 7N7J (X-ray 2.10A ) 7N7K (X-ray 2.00A ) 7N7L (X-ray 2.70A ) 7N7M (X-ray 2.60A ) 7N7N (X-ray 2.30A ) 7N7O (X-ray 2.70A ) |
| DBSNP | rs11813789 rs2230469 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:O70172}. Nucleus {ECO:0000269|PubMed:20583997}. Lysosome {ECO:0000250|UniProtKB:O70172}. Cytoplasm {ECO:0000269|PubMed:20583997}. Photoreceptor inner segment {ECO:0000250|UniProtKB:O70172}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:O70172}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250|UniProtKB:O70172, ECO:0000269|PubMed:20583997}. |
| Mouse PG classification | NA |
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