| Gene Information | |
|---|---|
| Gene Name | STEAP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 488 |
| Protein Names | Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000115107 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q658P3 |
| Gene Card | STEAP3 |
| Uniprot ID | Q658P3 |
| Pfam | PF03807; PF01794 |
| In ASD | no |
| Allosteric Prediction | yes (0.045359949) |
| Ortholog in Animals | Alpaca_ STEAP3 ( ortholog_one2one ) Dog_ STEAP3 ( ortholog_one2one ) GuineaPig_ STEAP3 ( ortholog_one2one ) Macaque_ STEAP3 ( ortholog_one2one ) Mouse_ Steap3 ( ortholog_one2one ) Pig_ STEAP3 ( ortholog_one2one ) Rat_ Steap3 ( ortholog_one2one ) Rabbit_ STEAP3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | STEAP1B, STEAP1, STEAP2, STEAP4 |
| Tissue | NA |
| Tissue Specificity | Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. {ECO:0000269|PubMed:12606722, ECO:0000269|PubMed:15885357, ECO:0000269|PubMed:16227996}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2VNS (X-ray 2.00A ) 2VQ3 (X-ray 2.00A ) |
| DBSNP | rs17013371 |
| Subcellular location [CC] | Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus. |
| Mouse PG classification | NA |
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