| Gene Information | |
|---|---|
| Gene Name | PTPN7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000143851 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P35236 |
| Gene Card | PTPN7 |
| Uniprot ID | P35236 |
| Pfam | PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.361009592) |
| Ortholog in Animals | Alpaca_ PTPN7 ( ortholog_one2one ) Dog_ PTPN7 ( ortholog_one2one ) GuineaPig_ PTPN7 ( ortholog_one2one ) Macaque_ PTPN7 ( ortholog_one2one ) Mouse_ Ptpn7 ( ortholog_one2one ) Pig_ PTPN7 ( ortholog_one2one ) Rat_ Ptpn7 ( ortholog_one2one ) |
| Ohnologs | PTPN5, PTPRR |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | Expressed exclusively in thymus and spleen. {ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZC0 (X-ray 1.85A ) 2A3K (X-ray 2.55A ) 2GP0 (X-ray 2.05A ) 2GPH (X-ray 1.90A ) 2HVL (X-ray 2.40A ) 2QDC (X-ray 2.00A ) 2QDM (X-ray 2.05A ) 2QDP (X-ray 2.72A ) 3D42 (X-ray 2.46A ) 3D44 (X-ray 1.90A ) 3O4S (X-ray 1.90A ) 3O4T (X-ray 2.60A ) 3O4U (X-ray 2.25A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14613483}. Cytoplasm, cytoskeleton {ECO:0000250}. |
| Mouse PG classification | NA |
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