| Gene Information | |
|---|---|
| Gene Name | PIM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 311 |
| Protein Names | Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h) |
| Target Name | serine/threonine-protein kinase pim-2 |
| Target Type | Clinical trial target |
| Gene Age | 168 ( ENSG00000102096 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P1W9 |
| Gene Card | PIM2 |
| Uniprot ID | Q9P1W9 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.350062606) |
| Ortholog in Animals | Alpaca_ PIM2 ( ortholog_one2one ) Dog_ PIM2 ( ortholog_one2one ) GuineaPig_ PIM2 ( ortholog_one2one ) Macaque_ PIM2 ( ortholog_one2one ) Mouse_ Pim2 ( ortholog_one2one ) Pig_ PIM2 ( ortholog_one2one ) Rat_ Pim2 ( ortholog_one2one ) |
| Ohnologs | PIM1, PIM3 |
| Paralogs | PIM3, PIM1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues. {ECO:0000269|PubMed:18675992}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2IWI (X-ray 2.80A ) 4X7Q (X-ray 2.33A ) |
| DBSNP | rs35044770 rs35208542 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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