| Gene Information | |
|---|---|
| Gene Name | PILRA |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000085514 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9UKJ1 |
| Gene Card | PILRA |
| Uniprot ID | Q9UKJ1 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-1.57730762) |
| Ortholog in Animals | Alpaca_ PILRA ( ortholog_one2many ) Macaque_ PILRA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PILRB |
| Tissue | NA |
| Tissue Specificity | Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. {ECO:0000269|PubMed:10903717}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3WUZ (X-ray 1.30A ) 3WV0 (X-ray 2.30A ) 4NFB (X-ray 1.60A ) 5XO2 (X-ray 2.20A ) 5XOF (X-ray 1.96A ) |
| DBSNP | rs1859788 rs34266222 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 3]: Secreted {ECO:0000305}.; [Isoform 4]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |