| Gene Information | |
|---|---|
| Gene Name | PRICKLE3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 615 |
| Protein Names | Prickle planar cell polarity protein 3 (LIM domain only protein 6) (LMO-6) (Prickle-like protein 3) (Pk3) (Triple LIM domain protein 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000012211 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43900 |
| Gene Card | PRICKLE3 |
| Uniprot ID | O43900 |
| Pfam | PF00412; PF06297 |
| In ASD | no |
| Allosteric Prediction | no (-0.825875714) |
| Ortholog in Animals | Alpaca_ PRICKLE3 ( ortholog_one2one ) Dog_ PRICKLE3 ( ortholog_one2one ) GuineaPig_ PRICKLE3 ( ortholog_one2one ) Macaque_ PRICKLE3 ( ortholog_one2one ) Mouse_ Prickle3 ( ortholog_one2one ) Pig_ PRICKLE3 ( ortholog_one2one ) Rat_ Prickle3 ( ortholog_one2one ) |
| Ohnologs | PRICKLE1, PRICKLE2 |
| Paralogs | PRICKLE2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7065449 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:A8WH69, ECO:0000269|PubMed:32516135}. Cell membrane {ECO:0000250|UniProtKB:A8WH69}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WH69}; Cytoplasmic side {ECO:0000250|UniProtKB:A8WH69}. Mitochondrion {ECO:0000269|PubMed:32516135}. Note=Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity). {ECO:0000250|UniProtKB:A8WH69}. |
| Mouse PG classification | NA |
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