| Gene Information | |
|---|---|
| Gene Name | PIK3C2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1634 |
| Protein Names | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta) |
| Target Name | phosphatidylinositol 4-phosphate 3-kinase c2 domain-containing subunit beta |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000133056 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00750 |
| Gene Card | PIK3C2B |
| Uniprot ID | O00750 |
| Pfam | PF00168; PF00454; PF00792; PF00794; PF00613; PF00787 |
| In ASD | no |
| Allosteric Prediction | no (-0.002348437) |
| Ortholog in Animals | Alpaca_ PIK3C2B ( ortholog_one2one ) Dog_ PIK3C2B ( ortholog_one2one ) GuineaPig_ PIK3C2B ( ortholog_one2one ) Macaque_ PIK3C2B ( ortholog_one2one ) Mouse_ Pik3c2b ( ortholog_one2one ) Pig_ PIK3C2B ( ortholog_one2one ) Rat_ Pik3c2b ( ortholog_one2one ) Rabbit_ PIK3C2B ( ortholog_one2one ) |
| Ohnologs | PIK3C2A, PIK3C2G |
| Paralogs | PIK3CG, PIK3CB, PIK3C2A, PI4KB, PIK3CA, PI4KA, PIK3C2G, PIK3C3, PIK3CD |
| Tissue | NA |
| Tissue Specificity | Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9144573}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Microsome {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9830063}. Cell membrane {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9830063}. Cytoplasm, cytosol {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9830063}. Nucleus {ECO:0000269|PubMed:14563213}. Endoplasmic reticulum {ECO:0000269|PubMed:14563213}. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis. |
| Mouse PG classification | NA |
| click here to return to the previous page | |