Gene Information
Gene NameGRB7
OrganismHomo sapiens (Human)
Gene Length532
Protein NamesGrowth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000141738 )
Evolutionary StageEumetazoa
AlphaFoldDBQ14451
Gene CardGRB7
Uniprot IDQ14451
PfamPF08947; PF00169; PF00788; PF00017
In ASDno
Allosteric Predictionyes (0.246933787)
Ortholog in AnimalsAlpaca_ GRB7 ( ortholog_one2one )
Dog_ GRB7 ( ortholog_one2one )
GuineaPig_ GRB7 ( ortholog_one2one )
Macaque_ GRB7 ( ortholog_one2one )
Mouse_ Grb7 ( ortholog_one2one )
Pig_ GRB7 ( ortholog_one2one )
Rat_ Grb7 ( ortholog_one2one )
Rabbit_ GRB7 ( ortholog_one2one )
OhnologsGRB10, GRB14
ParalogsAPBB1IP, RAPH1, GRB10, GRB14
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);0.029817(Mouse);NULL(Rat);0.018182(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1MW4  (NMR  -  )  1WGR  (NMR  -  )  2L4K  (NMR  -  )  2QMS  (X-ray  2.10A  )  3PQZ  (X-ray  2.41A  )  4WWQ  (X-ray  1.80A  )  4X6S  (X-ray  2.55A  )  5D0J  (X-ray  2.60A  )  5EEL  (X-ray  2.47A  )  5EEQ  (X-ray  1.60A  )  5TYI  (X-ray  2.15A  )  5U06  (X-ray  2.10A  )  5U1Q  (X-ray  2.10A  )  7MP3  (X-ray  2.55A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:18853468}. Cell junction, focal adhesion {ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278}. Cell membrane;
Peripheral membrane protein;
Cytoplasmic side {ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:18853468}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q03160}. Cell projection {ECO:0000269|PubMed:18853468}. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. {ECO:0000250|UniProtKB:Q03160}.
Mouse PG classificationNA
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