| Gene Information | |
|---|---|
| Gene Name | AGR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 175 |
| Protein Names | Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000106541 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O95994 |
| Gene Card | AGR2 |
| Uniprot ID | O95994 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | yes (0.268808482) |
| Ortholog in Animals | Alpaca_ AGR2 ( ortholog_one2one ) Dog_ AGR2 ( ortholog_one2one ) GuineaPig_ AGR2 ( ortholog_one2one ) Macaque_ AGR2 ( ortholog_one2one ) Mouse_ Agr2 ( ortholog_one2one ) Pig_ AGR2 ( ortholog_one2one ) Rat_ Agr2 ( ortholog_one2one ) Rabbit_ AGR2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AGR3, TXNDC12 |
| Tissue | stomach, transverse.colon |
| Tissue Specificity | Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. {ECO:0000269|PubMed:9790916}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LNS (NMR - ) 2LNT (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15834940}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O88312}. |
| Mouse PG classification | NA |
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