| Gene Information | |
|---|---|
| Gene Name | HCAR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 363 |
| Protein Names | Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor) |
| Target Name | hydroxycarboxylic acid receptor 2 |
| Target Type | NA |
| Gene Age | 8 ( ENSG00000182782 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TDS4 |
| Gene Card | HCAR2 |
| Uniprot ID | Q8TDS4 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.12244239) |
| Ortholog in Animals | Dog_ HCAR2 ( ortholog_one2many ) Mouse_ Hcar2 ( ortholog_one2many ) Rat_ Hcar2 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | P2RY2, P2RY4, OXGR1, P2RY1, SUCNR1, P2RY6, FFAR3, GPR42, FFAR2, HCAR3, HCAR1, OXER1, GPR31, FFAR1, GPR82 |
| Tissue | whole.blood |
| Tissue Specificity | Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. {ECO:0000269|PubMed:12522134, ECO:0000269|PubMed:17932499}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs676770 rs676823 rs7314976 rs2454727 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17932499}; Multi-pass membrane protein {ECO:0000269|PubMed:17932499}. |
| Mouse PG classification | NA |
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