| Gene Information | |
|---|---|
| Gene Name | NRXN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1477 |
| Protein Names | Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) |
| Target Name | neurexin-1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000179915 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9ULB1 |
| Gene Card | NRXN1 |
| Uniprot ID | Q9ULB1 |
| Pfam | PF00008; PF02210 |
| In ASD | no |
| Allosteric Prediction | yes (0.538414192) |
| Ortholog in Animals | Alpaca_ NRXN1 ( ortholog_one2one ) Dog_ NRXN1 ( ortholog_one2one ) Macaque_ NRXN1 ( ortholog_one2one ) Mouse_ Nrxn1 ( ortholog_one2one ) Pig_ NRXN1 ( ortholog_one2one ) Rat_ Nrxn1 ( ortholog_one2one ) Rabbit_ NRXN1 ( ortholog_one2one ) |
| Ohnologs | NRXN3, NRXN2 |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRP1, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum, tibial.nerve |
| Tissue Specificity | Brain. {ECO:0000269|PubMed:9628581}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6NID (X-ray 1.86A ) |
| DBSNP | rs199598542 rs17040901 |
| Subcellular location [CC] | Presynaptic cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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