| Gene Information | |
|---|---|
| Gene Name | IL12RB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 862 |
| Protein Names | Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000081985 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99665 |
| Gene Card | IL12RB2 |
| Uniprot ID | Q99665 |
| Pfam | PF00041; PF06328 |
| In ASD | no |
| Allosteric Prediction | no (-0.087225317) |
| Ortholog in Animals | Alpaca_ IL12RB2 ( ortholog_one2one ) Dog_ IL12RB2 ( ortholog_one2one ) Macaque_ IL12RB2 ( ortholog_one2one ) Mouse_ Il12rb2 ( ortholog_one2one ) Pig_ IL12RB2 ( ortholog_one2one ) Rat_ Il12rb2 ( ortholog_one2one ) Rabbit_ IL12RB2 ( ortholog_one2one ) |
| Ohnologs | LIFR, OSMR, IL31RA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed at similar levels in both naive and activated T-cells. {ECO:0000269|PubMed:9120388}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17129772 rs17129792 rs2307146 rs7526769 rs2307148 rs2307148 rs2307145 rs2307153 rs2307154 rs1242019108 rs17838066 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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