| Gene Information | |
|---|---|
| Gene Name | PICOT |
| Organism | Homo sapiens (Human) |
| Gene Length | 335 |
| Protein Names | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O76003 |
| Gene Card | GLRX3 |
| Uniprot ID | O76003 |
| Pfam | PF00462; PF00085 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002490(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DIY (NMR - ) 2WZ9 (X-ray 1.55A ) 2YAN (X-ray 1.90A ) 3ZYW (X-ray 1.84A ) |
| DBSNP | rs13991 rs2274217 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000305|PubMed:27519415}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9CQM9}. Note=Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250|UniProtKB:Q9CQM9}. |
| Mouse PG classification | NA |
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