| Gene Information | |
|---|---|
| Gene Name | PIAS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 651 |
| Protein Names | E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000033800 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75925 |
| Gene Card | PIAS1 |
| Uniprot ID | O75925 |
| Pfam | PF14324; PF02891 |
| In ASD | no |
| Allosteric Prediction | yes (0.637459244) |
| Ortholog in Animals | Alpaca_ PIAS1 ( ortholog_one2one ) Dog_ PIAS1 ( ortholog_one2one ) GuineaPig_ PIAS1 ( ortholog_one2one ) Macaque_ PIAS1 ( ortholog_one2one ) Mouse_ Pias1 ( ortholog_one2one ) Pig_ PIAS1 ( ortholog_one2one ) Rat_ Pias1 ( ortholog_one2one ) Rabbit_ PIAS1 ( ortholog_one2one ) |
| Ohnologs | PIAS2, PIAS4, PIAS3 |
| Paralogs | PIAS3, PIAS2, PIAS4, ZMIZ2, ZMIZ1 |
| Tissue | NA |
| Tissue Specificity | Expressed in numerous tissues with highest level in testis. {ECO:0000269|PubMed:11439351, ECO:0000269|PubMed:9177271}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1V66 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton. |
| Mouse PG classification | NA |
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